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Myostatin inhibitory peptide 3d

Product Information Product Name Myostatin inhibitory peptide 3d Documents Sequence Shortening XRQNTRYSRIEWIKIQIISKLRL-NH2(X = 2-naphthoxyacetyl group) Length (aa) 23 Peptide Purity (HPLC) 95.8% Molecular Formula C139H225N41O33 Molecular Weight 2998.57 Source Synthetic Form Powder Description Myostatin, a negative regulator of skeletal muscle growth, is a promising target for treating muscle atrophic disorders. A novel peptide myostatin inhibitory peptide 3d displayed an IC50 value of 0.32 μM, which is 11 times more potent than peptide(WRQNTRYSRIEAIKIQILSKLRL-amide). The peptide 3d would have the potential to be a promising drug lead to develop better peptidomimetics. Storage Guidelines Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides References Takayama K, Rentier C, Asari T, et al. Development of Potent Myostatin Inhibitory Peptide

Context first

Study findings do not automatically establish clinical benefit, safety, dosing, or suitability for an individual.

Product Information

Product Name

Myostatin inhibitory peptide 3d Documents Sequence Shortening

XRQNTRYSRIEWIKIQIISKLRL-NH2(X = 2-naphthoxyacetyl group) Length (aa)

23 Peptide Purity (HPLC)

95.8% Molecular Formula

C139H225N41O33 Molecular Weight

2998.57 Source

Synthetic Form

Powder Description

Myostatin, a negative regulator of skeletal muscle growth, is a promising target for treating muscle atrophic disorders. A novel peptide myostatin inhibitory peptide 3d displayed an IC50 value of 0.32 μM, which is 11 times more potent than peptide(WRQNTRYSRIEAIKIQILSKLRL-amide). The peptide 3d would have the potential to be a promising drug lead to develop better peptidomimetics. Storage Guidelines

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides References

Takayama K, Rentier C, Asari T, et al. Development of Potent Myostatin Inhibitory Peptides through Hydrophobic Residue-Directed Structural Modification. ACS Med Chem Lett. 2017;8(7):751-756 About TFA salt

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

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