Ipamorelin
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Product Format
10mg vials
Vial Size
10mg
Box Combinations
20mg, 50mg, 100mg, 200mg
Cost per milligram
$2.88 – $4.10
Multi-vial Purity
99.92%
Endotoxin Screening
PASSED
Heavy Metals Screening
PASSED
Purity Screening
PASSED
Independently Tested
YES
Peptide Partners Manufacturer Id: WF03
Batch Id: IP202601
Research Studies
(for educational purposes only)
Study 1: Ipamorelin, the first selective growth hormone secretagogue
Authors: K Raun, B S Hansen, N L Johansen, H Thøgersen, K Madsen, M Ankersen, P H Andersen
Source: https://pubmed.ncbi.nlm.nih.gov/9849822/
Scientific Findings
In vitro, ipamorelin released GH from primary rat pituitary cells with a potency and efficacy similar to GHRP-6 (EC50 = 1.3+/-0.4nmol/l and Emax = 85+/-5% vs 2.2+/-0.3nmol/l and 100%). A pharmacological profiling using GHRP and growth hormone-releasing hormone (GHRH) antagonists clearly demonstrated that ipamorelin, like GHRP-6, stimulates GH release via a GHRP-like receptor. The specificity for GH release was studied in swine. None of the GH secretagogues tested affected FSH, LH, PRL or TSH plasma levels. Administration of both GHRP-6 and GHRP-2 resulted in increased plasma levels of ACTH and cortisol. Very surprisingly, ipamorelin did not release ACTH or cortisol in levels significantly different from those observed following GHRH stimulation. This lack of effect on ACTH and cortisol plasma levels was evident even at doses more than 200-fold higher than the ED50 for GH release. In conclusion, ipamorelin is the first GHRP-receptor agonist with a selectivity for GH release similar to that displayed by GHRH.
Plain English Interpretation
Scientists have developed a new compound called ipamorelin that can stimulate the release of growth hormone (GH). In laboratory experiments using rat pituitary cells, ipamorelin was found to be as effective as a similar compound, GHRP-6, in releasing GH. The study also showed that ipamorelin works by activating a specific receptor in the pituitary gland. Unlike other similar compounds, ipamorelin is very selective and does not cause the release of other hormones like cortisol or ACTH, which are stress-related hormones. This makes ipamorelin a promising candidate for future clinical use as a safe and effective way to boost growth hormone levels.
Study 2: The influence of ghrelin agonist ipamorelin acetate on the hypothalamic-pituitary-testicular axis in a cichlid fish, Oreochromis mossambicus
Authors: Mallikarjun Gouda, C.B. Ganesh
Source: https://www.sciencedirect.com/science/article/pii/S0378432024001416
Scientific Findings
The administration of either 5 or 30 μg of IPA for 21 days led to a significant and dose-dependent rise in food intake concomitant with a significant increase in the numbers of primary spermatocytes, secondary spermatocytes, and early spermatids compared to the control group. There was a significant rise in the number of late spermatids, as well as the areas of the lobule and lumen, in fish treated with 30 μg of IPA, compared to the control group. Moreover, there was no significant difference in the percentage of gonadotropin-releasing hormone (GnRH)-immunoreactive fibres in the hypothalamus and anterior pituitary gland across different groups. However, a significant elevation in the expression of androgen receptor protein was observed in fish treated with 30 μg of IPA. Furthermore, the concentrations of luteinizing hormone (LH) and 11-ketotestosterone (11-KT) in the serum of fish treated with either 5 or 30 μg of IPA were significantly elevated in comparison to the control group. Collectively, these findings suggest that the administration of ghrelin enhances the development of germ cells during the meiosis-I phase and that this effect might be mediated via the stimulation of 11-KT and androgen receptors at the testicular level and LH at the pituitary level in the tilapia.
Plain English Interpretation
In a study on tilapia fish, researchers found that giving them a substance called ipamorelin acetate (IPA) for 21 days made them eat more and produced more sperm cells. The fish that got a higher dose of IPA had more mature sperm and larger reproductive tissues. While the treatment didn’t change the levels of a key reproductive hormone in the brain, it did increase the levels of another hormone that stimulates testosterone production. This suggests that ipamorelin helps to improve fertility in fish by boosting sperm development through a complex hormonal process.
Study 3: Detection of the synthetic peptide ipamorelin in dried blood spots by means of UHPLC-HRMS
Authors: Enrico Gerace, Jessica Modaffari, Pierre Negri, Daniele Di Corcia, Eleonora Amante, Alberto Salomone, Marco Vincenti
Source: https://www.sciencedirect.com/science/article/abs/pii/S1387380621000117
Scientific Findings
A simple and effective procedure based on a fast methanolic extraction and a LC-HRMS detection of the growth hormone secretagogue ipamorelin in DBS was recently proposed by Gerace et al. [193]. MS and MS/MS data were collected by a Q-TOF mass spectrometer operating in the positive ESI mode.
Plain English Interpretation
Researchers have developed a new method to detect the synthetic peptide ipamorelin in dried blood spots. This method is simple, fast, and effective. It uses a technique called liquid chromatography-high resolution mass spectrometry (LC-HRMS) to identify and measure the amount of ipamorelin in the blood sample. This new method could be useful for a variety of applications, including monitoring the use of ipamorelin in athletes.
Storage:
All of our manufacturing partners produce peptides using the Lyophilization (Freeze Drying) process, ensuring products maintain stability for shipping and storage for 12+ months.
In lyophilized form, they are shelf-stable for many weeks. However, for long-term storage, it is recommended to store them in the freezer.
We often hear concerns about the standard “discard after 28 days of first use” disclaimer. Don’t worry, this has nothing to do with studies regarding the efficacy of specific peptides. 28 days is the FDA requirement for producers of multi-use vials to prove their bacteriostatic maintains efficacy. This minimum requirement becomes the de facto standard.
In our experience, if you use proper sterile procedures and refrigerated storage, you can continue sampling from the same reconstituted vial for 3+ months.
Third-party testing
Peptide Partners is committed to providing high-purity peptides at wholesale prices by frequently auditing its manufacturing partners using third-party laboratories. Independent analysis is vital to ensuring the quality and authenticity of your research peptides. Never trust a supplier that doesn’t submit to third-party testing. Never trust a certification that cannot be independently verified. All of the certificates that we provide can be validated on the third-party laboratory’s website.
Each product description contains a Manufacturer ID corresponding to the producer of that product. The table below contains the most recent third-party analyses for all manufacturers and peptides listed on Peptide Partners.
Current Purity certifications
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Current Endotoxin Certifications
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Current Heavy Metal Certifications
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Current Sterility Certifications
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Verifiable certificates
When obtaining research peptides, it is essential to validate the authenticity of the Certificate of Analysis (COA). Certificate fraud runs rampant throughout the research peptide supply community. The two most common forms are doctored images and stolen certificates. You can check for these two by making sure the third-party laboratory’s website shows that the certificate belongs to the supplier and the values haven’t been doctored. TrustPointe Analytics provides a few simple rules for verification:
When obtaining research peptides, it is essential to validate the authenticity of the Certificate of Analysis (COA). Certificate fraud runs rampant throughout the research peptide supply community. The two most common forms are doctored images and stolen certificates. You can check for these two by making sure the third-party laboratory’s website shows that the certificate belongs to the supplier and the values haven’t been doctored. TrustPointe Analytics provides a few simple rules for verification:
Beware of fraudulent laboratories
Not only must one remain vigilant about potentially fraudulent certificates, one must also be aware that there are third-party laboratories whose results cannot be considered reliable or scientifically valid. Unfortunately, there is significant evidence to suggest that one of the most popular third-party testing labs does not use scientifically sound methodologies and, in some cases, has fabricated results. There isn’t an easy remedy for this problem, but when labs are particularly bad, there tend to be a lot of discussion threads on various social platforms.
Interpreting Endotoxin Results (via TrustPointe)
Our friends at TrustPointe have provided the following detailed explanation to help interpret the results of the endotoxin testing.
We use the Charles River Endosafe PTS system to test for bacterial endotoxins following USP <85> guidelines:
USP <85> Bacterial Endotoxin Result: <x.xx EU/mL Because it’s reported as “<x.xx” this indicates the test did not detect endotoxin above the detection limit of the cartridge. If a result is above the limit of detection of the cartridge, it will be reported as a number (without the “<“).
The following are suitability parameters that verify the system was working properly and the sample prep dilution is appropriate for accurate results. Peptides often interfere with endotoxin detection due to their tendency to bind or mask endotoxins, which can lead to inaccurate low results. To overcome this, samples are typically tested at a large dilution to reduce matrix interference and ensure reliable recovery and detection in compliance with USP <85>. If the dilution is not correct, the run will fail suitability and we’ll need to adjust the dilution to ensure accurate results. We provide the suitability data to customers for transparency and so they can be confident in the results.
USP <85> Sample CV %:
CV stands for coefficient of variation, a measure of repeatability. For our lab, CV has to be <25% or the result to be considered valid
USP <85> Spike CV %:
This refers to the precision of the positive control (spiked sample). Again, for our lab CV has to be <25% or the result to be considered valid
USP <85> Spike Recovery
This tells us how much of the known endotoxin spike was recovered from your sample. The acceptable range is 50–200% per USP <85>