Thymosin beta-4 is the parent peptide of TB-500 — endogenous, 43 amino acids, highly conserved. Goldstein 2012 reviews the mechanistic literature: TB4 promotes cell migration, angiogenesis, and matrix remodeling across multiple tissue types. Most clinical claims rest on the same animal literature as TB-500 (mouse cardiac MI, rat wound, mouse hair follicle).
0 human studies · 18 animal studies
Cell migration and tubule formation enhanced in vitro.
Mouse wound closure accelerated ~40% in full-thickness models.
Endogenous, present at high concentrations in platelets.
RegeneRx development program as a regenerative cardiac therapy did not complete Phase 3.
Top citations
Goldstein 2012 — Mechanistic review
Malinda 1999 — Wound healing
Our take
The full peptide rather than the TB-500 fragment. Mechanistically more complete, clinically equally untested in humans — claims should be calibrated accordingly.