Product Details
IGF-1 LR3 (Media Grade) is a synthetic peptide analog of insulin-like growth factor-1 (IGF-1), modified to alter its structural and receptor interaction properties. This modification supports extended stability and enables detailed investigation in controlled research environments.
Within laboratory settings, IGF-1 LR3 is utilized to examine receptor-ligand interactions and intracellular signaling pathways associated with growth factor systems. Its structure allows for consistent evaluation of peptide binding dynamics and signal transduction mechanisms at the molecular level.
This compound is supplied strictly for laboratory research purposes and is not intended for consumption, medical, or diagnostic use.
Mechanism of Action
At the molecular level, IGF-1 LR3 is studied for its interaction with insulin-like growth factor-1 receptors (IGF-1R) and related receptor systems. Upon binding, the receptor-ligand complex initiates intracellular signaling cascades involving pathways such as phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt), as well as mitogen-activated protein kinase (MAPK) signaling.
These signaling pathways are analyzed in vitro to evaluate their role in cellular communication, transcriptional regulation, and protein synthesis processes. Researchers examine how ligand binding influences receptor activation, downstream signaling propagation, and gene expression patterns.
Additionally, IGF-1 LR3 is investigated for its interaction with insulin-like growth factor binding proteins (IGFBPs), which regulate peptide availability and receptor engagement. These studies contribute to a broader understanding of growth factor signaling and molecular regulation under controlled experimental conditions.
Chemical Properties of IGF-1 LR3 (Media Grade)
Attribute Details Compound Name IGF-1 LR3 Classification Synthetic peptide (IGF-1 analog) Molecular Formula C400H625N111O115S9 Molecular Weight 9117.60 g/mol CAS Number 946870-92-4 IUPAC Name Insulin-like growth factor-1 long arginine 3 Synonyms IGF-I; IGF1A; IGFI Primary Target IGF-1 receptor (IGF-1R) Research Context Growth factor signaling and receptor interaction studies Format Research peptide (non-consumable) Stability Maintained under controlled laboratory storage conditions
Research Applications
Receptor Binding and Signal Transduction Studies
IGF-1 LR3 is utilized in experimental systems to evaluate ligand interaction with IGF-1 receptors. Researchers analyze receptor activation, binding affinity, and downstream signaling cascades at the molecular level.
Intracellular Pathway Analysis
This compound is applied in studies investigating signaling pathways such as PI3K/Akt and MAPK. These analyses focus on transcriptional regulation and protein synthesis mechanisms associated with receptor activation.
Peptide-Protein Interaction Research
IGF-1 LR3 supports investigations into interactions with binding proteins such as IGFBPs. These studies examine how binding proteins influence peptide stability, availability, and receptor engagement.
Why Choose BehemothLabz to Buy IGF-1 LR3 for Research
BehemothLabz provides research-grade IGF-1 LR3 manufactured under controlled laboratory conditions with strict quality assurance protocols. Each batch undergoes analytical verification to ensure consistency in molecular composition and purity.
Comprehensive documentation, including laboratory testing reports and sourcing transparency, supports reproducibility in experimental settings. BehemothLabz maintains a compliance-focused approach, supplying compounds intended strictly for laboratory-based investigation and analytical research
Disclaimer
IGF-1 LR3 is intended strictly for laboratory research and analytical purposes only. It is not intended for use in diagnostic procedures, therapeutic applications, or in vivo studies of any kind.
Any references to biochemical pathways, receptor interactions, or enzymatic processes are provided solely for informational and research-context purposes. This compound must be handled exclusively by qualified professionals in controlled laboratory environments in accordance with applicable regulations and safety guidelines.
Improper handling or use outside of controlled research settings is strictly prohibited.
References
White, A., Stremming, J., Wesolowski, S. R., Al-Juboori, S. I., Dobrinskikh, E., Limesand, S. W., Brown, L. D., & Rozance, P. J. (2025). IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep. American journal of physiology. Endocrinology and metabolism, 328(1), E116–E125. https://doi.org/10.1152/ajpendo.00259.2024 Lu, Z., Liu, N., Huang, H., Wang, Y., Tu, T., Qin, X., Wang, X., Zhang, J., Su, X., Tian, J., Bai, Y., Luo, H., Yao, B., & Zhang, H. (2023). Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris. Applied microbiology and biotechnology, 107(14), 4543–4551. https://doi.org/10.1007/s00253-023-12606-0