Review
. 2024 Sep 30;97(3):399-413.
doi: 10.59249/TKNM3388. eCollection 2024 Sep.
Affiliations
PMID: 39351323 PMCID: PMC11426299 DOI: 10.59249/TKNM3388
Review
Local and Systemic Peptide Therapies for Soft Tissue Regeneration: A Narrative Review
Caroline J Cushman et al. Yale J Biol Med. 2024.
Abstract
Background: The musculoskeletal system, due to inherent structure and function, lends itself to contributing toward joint pain, whether from inflammatory disorders such as rheumatoid arthritis, degenerative diseases such as osteoarthritis, or trauma causing soft tissue injury. Administration of peptides for treatment of joint pain or inflammation is an emerging line of therapy that seeks to offer therapeutic benefits while remaining safe and relatively non-invasive. Purpose: The purpose of this study is to review the current literature on existing oral peptide agents, intra-articular peptide agents, and new developments in human trials to assess route of administration (RoA) for drug delivery in terms of soft tissue regeneration. Study Design: Narrative Review. Methods: A comprehensive literature search was conducted using the PubMed database. The search included medical subject headings (MeSH) terms related to peptide therapy, soft tissue regeneration, and RoA. Inclusion criteria comprised articles focusing on the mechanisms of action of peptides, clinical or biochemical outcomes, and review articles. Exclusion criteria included insufficient literature or studies not meeting the set evidence level. Conclusion: The review identified various peptides demonstrating efficacy in soft tissue repair. Oral and intra-articular peptides showed distinct advantages in soft tissue regeneration, with intra-articular routes providing localized effects and oral routes offering systemic benefits. However, both routes have limitations in bioavailability and absorption. Still in their infancy, further inquiries/research into the properties and efficacy of emerging peptides will be necessary before widespread use. As a viable alternative prior to surgical intervention, peptide treatments present as promising candidates for positive outcomes in soft tissue regeneration.
Keywords: Local; Musculoskeletal; Peptides; Systemic; Therapy.
Copyright ©2024, Yale Journal of Biology and Medicine.
PubMed Disclaimer
References
Dahlhamer J, Lucas J, Zelaya C, Nahin R, Mackey S, DeBar L, et al. Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults - United States. MMWR Morb Mortal Wkly Rep. 2018;67(36):1001-6. Epub. 2016;20180914: https://doi.org/ 10.15585/mmwr.mm6736a2. - DOI - PMC - PubMed
Al Attia HM, Al Abbasi M. Sensing the main health concerns in patients with established rheumatoid arthritis. Clin Rheumatol. 2011;30(11):1511-4. Epub 20110927. https://doi.org/ 10.1007/s10067-011-1853-8. - DOI - PubMed
Wood MJ, Miller RE, Malfait AM. The Genesis of Pain in Osteoarthritis: Inflammation as a Mediator of Osteoarthritis Pain. Clin Geriatr Med. 2022. May;38(2):221–38. 10.1016/j.cger.2021.11.013 - DOI - PMC - PubMed
Lieberthal J, Sambamurthy N, Scanzello CR. Inflammation in joint injury and post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2015. Nov;23(11):1825–34. 10.1016/j.joca.2015.08.015 - DOI - PMC - PubMed
Yelin E, Weinstein S, King T. The burden of musculoskeletal diseases in the United States. Semin Arthritis Rheum. 2016;46(3):259-60. Epub 20160726. https://doi.org/ 10.1016/j.semarthrit.2016.07.013. - DOI - PubMed