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AMPK activator
AICAR
AMPK activator
From: 160 USD
Size
50 mg
Catalog #
(Select a product)
AMPK activator
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Overview
AICAR is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain cellular energy homeostasis (Hardie and Carling).
MAINTENANCE & SELF-RENEWAL · Induces upregulation of the pluripotency network genes (Klf4, Klf2, Nanog, Oct4, Myc, Sox2) and epigenetic-associated proteins (Dnmt3a, Mbd3) in mouse ES cells, and inhibits retinoic acid-induced differentiation (Adamo et al.; Shi et al).
DIFFERENTIATION · Promotes differentiation and mineralization of MC3T3-E1 osteoblastic cells (Kanazawa et al.). · Inhibits proliferation and promotes osteogenic differentiation, while inhibiting adipogenic differentiation, of human amnion-derived mesenchymal stem cells (MSCs) and rabbit bone marrow-derived MSCs (Wu et al.). · Suppresses proliferation and induces astroglial differentiation in neural stem cells (NSCs) and in the immortalized NSC line C17.2 (C17.2-NSC; Zang et al. 2008, 2009). · Decreased proliferation and Nanog expression in mouse embryonic stem (ES) cells, with increased erythroid differentiation (Chae et al.)
Acadesine; AICA Riboside; NSC 105823
Mesenchymal Stem and Progenitor Cells, Neural Stem and Progenitor Cells, Osteoblasts, Pluripotent Stem Cells
Human, Mouse, Non-Human Primate, Other, Rat
Differentiation, Maintenance
Neuroscience, Stem Cell Biology
2627-69-2
C9H14N4O5
258.2 g/mol
≥ 98%
AMPK
AMPK
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
72704
Lot #
All
Language
English
Catalog #
72704
Lot #
All
Language
English
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.