Description
MK-677 (Ibutamoren) 10 mg — Oral GH Secretagogue & Ghrelin-Receptor Agonist for Research
MK-677 (Ibutamoren) is a non-peptide small-molecule growth hormone secretagogue that acts as an agonist at the ghrelin (GHS-R1a) receptor. In preclinical and human research, MK-677 has been investigated for its ability to increase endogenous growth hormone (GH) and IGF-1 levels and for exploratory effects on body composition, sleep, and metabolic markers.
What It Is
Class: Non-peptide GH secretagogue / ghrelin-receptor agonist Target: Growth hormone secretagogue receptor (GHS-R1a), related to endogenous ghrelin Research focus: GH/IGF-1 axis, body composition, appetite, and metabolic endpoints
Proposed Mechanisms (Preclinical)
Ghrelin Receptor & GH/IGF-1 Axis
Acts as an agonist at GHS-R1a, mimicking ghrelin at pituitary and hypothalamic sites. Stimulates pulsatile GH release in experimental models and human studies. Leads to secondary increases in IGF-1 and related downstream anabolic markers.
Appetite, Body Composition & Metabolism
Associated with increased appetite and caloric intake in many research settings. Explored for effects on lean mass, fat mass, and functional outcomes in selected cohorts. Model-dependent changes in glucose handling, lipids, and bone-turnover markers have been reported.
Selected Research Highlights
GH/IGF-1 Enhancement: MK-677 has been studied for sustained elevations of GH and IGF-1 with oral administration in both animal and human trials. Body-Composition Research: Experimental work has examined lean mass, fat mass, and muscle function as exploratory endpoints. Sleep & Neuroendocrine Effects: Some studies report changes in sleep architecture and neuroendocrine parameters, consistent with ghrelin-pathway engagement. Aging & Catabolic States: Investigated in models of aging, immobilization, or catabolic stress for potential impacts on GH-axis and body-composition markers.
Chemical & Handling Information
Type: Non-peptide small-molecule ghrelin-receptor agonist Form: Lyophilized powder for laboratory reconstitution Appearance: White to off-white powder
Specifications
Compound: MK-677 (Ibutamoren) Amount: 10 mg per tablet x 100 Tablets Form: Lyophilized powder Purity: ?99% (HPLC); COA per lot available Packaging: Sealed vials suitable for standard laboratory handling
Storage & Stability
Store lyophilized vials in a cool, dry place, protected from light and moisture. Refrigeration or freezing of the lyophilized compound is recommended for extended stability, according to laboratory SOPs. After reconstitution, store at 2–8 °C for short-term use. For long-term storage, aliquot and freeze at ?20 °C or below; avoid repeated freeze–thaw cycles.