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IGF-1 LR3
Synonyms / Designations: IGF-1 LR3, Long Arg3 IGF-1, Insulin-Like Growth Factor-1 LR3, Recombinant IGF-1 analogue CAS Number: 946870-92-4 Molecular Formula: C400H625N111O115S9 Molecular Weight: 9117.5 g/mol Peptide Classification: Synthetic analogue of insulin-like growth factor-1 (IGF-1) Purity: ≥ 99 % (HPLC, typical) Appearance: White to off-white lyophilised powder Pack Size: 1 mg (total) Storage: Desiccated, protected from light, stored at –20 °C Solubility: Soluble in sterile water and buffered aqueous solutions
Description & Mechanism
IGF-1 LR3 is a synthetic analogue of human insulin-like growth factor-1 (IGF-1) incorporating an arginine substitution at position 3 and an extended N-terminal sequence. These structural modifications reduce affinity for endogenous IGF binding proteins, resulting in altered stability and interaction characteristics in experimental systems compared to native IGF-1.
In biochemical and cellular research models, IGF-1 LR3 interacts with the IGF-1 receptor (IGF-1R), initiating intracellular signalling cascades associated with growth factor–mediated pathways. Research studies commonly examine receptor binding behaviour, downstream signalling kinetics, and comparative responses relative to native IGF-1. Observed molecular effects are dependent on experimental design, concentration, and model system and are used to investigate IGF-1 receptor signalling rather than defined biological or physiological outcomes.
Applications in Research
As a molecular tool for studying IGF-1 receptor binding and activation dynamics Investigation of growth factor–mediated intracellular signalling pathways In vitro studies comparing modified and native IGF-1 analogues Use as a reference compound in endocrine and peptide signalling research
Handling, Reconstitution & Stability
Weigh under dry conditions; peptide is hygroscopic Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements Avoid vigorous agitation during dissolution Filter sterilize if required (e.g. 0.22 μm) immediately prior to use Aliquot and store reconstituted solutions at –20 °C (or lower) to minimise degradation Avoid repeated freeze–thaw cycles
Specifications Summary
Parameter Typical Value / Range Purity (HPLC) ≥ 99 % Appearance White to off-white lyophilised powder Molecular Weight ~9117.5 g/mol Peptide Type Synthetic IGF-1 analogue Solubility Water, buffered aqueous solutions Storage –20 °C, desiccated, dark Pack Size 1 mg
Precautions & Notes
Experimental behaviour of IGF-1 LR3 is influenced by receptor expression, concentration, and exposure duration Modified IGF-1 analogues may exhibit signalling profiles distinct from native IGF-1 Buffer composition, pH, and ionic strength may affect peptide stability and assay performance Appropriate controls are recommended to distinguish specific from non-specific effects Intended strictly for laboratory research use; not for human or veterinary application
References
Francis G.L. et al. Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency. Journal of Molecular Endocrinology, 1992. https://pubmed.ncbi.nlm.nih.gov/1378742/
Tomas F.M. et al. Superior potency of infused IGF-I analogues which bind poorly to IGF-binding proteins is maintained when administered by injection. Journal of Endocrinology, 1996. https://pubmed.ncbi.nlm.nih.gov/8708565/
Ballard F.J. et al. Does IGF-I ever act through the insulin receptor? Cytokine & Growth Factor Reviews, 1996. https://pubmed.ncbi.nlm.nih.gov/8899293/
Keywords: IGF-1 LR3, Long Arg3 IGF-1, Insulin-Like Growth Factor Analogue, Synthetic Growth Factor
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