sermorelin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
Stem definition Drug id CAS RN growth hormone release-stimulating peptides 2433 86168-78-7
Description:
Molecule Description
Molfile Inchi Smiles
Synonyms:
sermorelin acetate sermorelin somatoliberin The biologically active fragment of human growth hormone-releasing factor, consisting of GHRH(1-29)-amide. This N-terminal sequence is identical in several mammalian species, such as human, pig, and cattle. It is used to diagnose or treat patients with GROWTH HORMONE deficiency.
Molecular weight: 3357.93 Formula: C149H246N44O42S CLOGP: LIPINSKI: 3 HAC: 86 HDO: 52 TPSA: 1446.90 ALOGS: -4.75 ROTB: 115
Drug dosage:
None
ADMET properties:
Property Value Reference Vd (Volume of distribution) 0.34 L/kg Lombardo F, Berellini G, Obach RS CL (Clearance) 39.30 mL/min/kg Lombardo F, Berellini G, Obach RS t_half (Half-life) 0.19 hours Lombardo F, Berellini G, Obach RS
Approvals:
Date Agency Company Orphan Dec. 28, 1990 FDA
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
Source Code Description ATC H01AC04 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES Somatropin and somatropin agonists ATC V04CD03 VARIOUS DIAGNOSTIC AGENTS OTHER DIAGNOSTIC AGENTS Tests for pituitary function CHEBI has role CHEBI:33295 diagnostic aid
Drug Use | Suggest Off label Use Form| |View source of the data|
Disease Relation SNOMED_ID DOID Pituitary dwarfism indication 367460001 DOID:0060870 Diagnostic Test for Growth Hormone Secretion indication
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
Dissociation level Dissociation constant Type (acidic/basic) pKa1 3.49 acidic pKa2 4.09 acidic pKa3 9.4 acidic pKa4 10.0 acidic pKa5 11.94 acidic pKa6 12.09 acidic pKa7 12.55 acidic pKa8 12.58 acidic pKa9 12.75 acidic pKa10 12.81 acidic pKa11 12.95 acidic pKa12 13.12 acidic pKa13 13.19 acidic pKa14 13.31 acidic pKa15 13.47 acidic pKa16 13.52 acidic pKa17 13.59 acidic pKa18 13.68 acidic pKa19 13.82 acidic pKa20 13.82 acidic pKa21 13.99 acidic pKa22 11.48 Basic pKa23 11.1 Basic pKa24 10.75 Basic pKa25 10.46 Basic pKa26 10.07 Basic pKa27 7.76 Basic
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
Target Class Pharos UniProt Action Type Activity value (-log[M]) Mechanism action Bioact source MoA source Growth hormone-releasing hormone receptor GPCR
Q02643
GHRHR_HUMAN AGONIST UNKNOWN IUPHAR
External reference:
ID Source 4019553 VUID N0000179347 NUI D02117 KEGG_DRUG 114466-38-5 SECONDARY_CAS_RN 4019553 VANDF 4019931 VANDF C0142046 UMLSCUI CHEBI:9118 CHEBI CHEMBL1201490 ChEMBL_ID CHEMBL2108862 ChEMBL_ID D017337 MESH_DESCRIPTOR_UI DB00010 DRUGBANK_ID 6998 IUPHAR_LIGAND_ID 6036 INN_ID 89243S03TE UNII 16132413 PUBCHEM_CID 56188 RXNORM 5456 MMSL d04259 MMSL 004104 NDDF 004160 NDDF 109203000 SNOMEDCT_US 395870004 SNOMEDCT_US 412303008 SNOMEDCT_US
Pharmaceutical products:
None