Tesamorelin
Tesamorelin is a synthetic analogue of growth hormone-releasing hormone (GHRH) developed for research involving growth hormone regulation and metabolic function. It acts on the anterior pituitary gland to stimulate endogenous growth hormone (GH) secretion, leading to downstream increases in insulin-like growth factor 1 (IGF-1). Due to its selective mechanism of action, Tesamorelin has been studied extensively in relation to visceral adipose tissue reduction, metabolic modulation, and endocrine system regulation.
Unlike exogenous growth hormone administration, Tesamorelin promotes physiological GH pulsatility by mimicking native GHRH signalling pathways. This mechanism allows researchers to investigate growth hormone dynamics, lipid metabolism, and body composition changes under controlled experimental conditions.
Product Summary Table
Chemical Name Tesamorelin Molar Mass 5109.9 Da (approximately) Chemical Formula C221H366N72O67S Synonyms Tesamorelin, GHRH analogue Classification Growth Hormone-Releasing Hormone (GHRH) Analogue Form Lyophilised peptide for reconstitution Country of Origin Australia Storage Store refrigerated between 1–4°C after reconstitution. Protect from light. Standard Research Purity ≥98%
In Vivo Research Benefits
Stimulates Endogenous Growth Hormone Release: Activates pituitary GHRH receptors to promote physiological GH pulsatility and increased IGF-1 production. Visceral Fat Reduction Research: Clinical studies have demonstrated reductions in abdominal visceral adipose tissue in specific populations. Metabolic Modulation: Investigated for its effects on lipid metabolism, triglyceride levels, and insulin sensitivity. Body Composition Studies: Explored for impacts on lean body mass preservation and fat mass reduction. Endocrine System Research: Useful in studying hypothalamic-pituitary axis signalling and hormonal feedback mechanisms.
Dosage and Administration
Dosage: Research dosing parameters vary depending on study design and experimental model. Form: Lyophilised peptide requiring reconstitution. Usage: Intended for controlled laboratory research involving growth hormone regulation, metabolic analysis, and body composition investigation.
Studies and Additional Info
https://clinicaltrials.gov/study/NCT06554717 https://pmc.ncbi.nlm.nih.gov/articles/PMC6766405/