BPC 157 acetate is an orally active peptide. BPC 157 acetate exhibits multiple activities such as promoting wound healing, tendon healing, neuroprotection, and gastrointestinal protection. BPC 157 acetate can be used in the research of tendon injury, burn, gastric ulcer, and neurological diseases.
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容量 価格(税別) 在庫状況 数量 5 mg $120 在庫あり 10 mg $190 在庫あり 25 mg $360 在庫あり 50 mg $550 在庫あり 100 mg $820 在庫あり 200 mg お問い合わせ 500 mg お問い合わせ
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製品説明
BPC 157 acetate is an orally active peptide. BPC 157 acetate exhibits multiple activities such as promoting wound healing, tendon healing, neuroprotection, and gastrointestinal protection. BPC 157 acetate can be used in the research of tendon injury, burn, gastric ulcer, and neurological diseases[1][2][3]. 体外実験
BPC 157 (acetate) (2 μg/mL; 7 days) significantly accelerates the outgrowth of tendon fibroblasts from Sprague-Dawley rat Achilles tendon explants[1]. BPC 157 (acetate) (2 μg/mL; 24 h) significantly increases the viability of Sprague-Dawley rat Achilles tendon fibroblasts cultured under oxidative stress induced by 0.1 mM H2O2[1]. BPC 157 (acetate) (0.5–2 μg/mL; 24 h) promotes the migration of cultured Sprague-Dawley rat Achilles tendon fibroblasts and induces increased F-actin formation[1]. BPC 157 (acetate) (0–2 μg/mL; 24 h) activates the FAK-paxillin pathway in cultured SD rat Achilles tendon fibroblasts[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Immunofluorescence[1]
Cell Line: Cultured Sprague-Dawley rat Achilles tendon fibroblasts (passages 2-4) Concentration: 2 μg/mL Incubation Time: 24 h Result: Increased F-actin (polymerized actin fibers, visualized as green fluorescence) levels notably relative to control cells with weak F-actin detection.
Western Blot Analysis[1]
Cell Line: Cultured Sprague-Dawley rat Achilles tendon fibroblasts (passages 2-4) Concentration: 0, 0.5, 1, 2 μg/mL Incubation Time: 24 h Result: Did not alter total FAK, paxillin, or PCNA protein levels. Increased the phosphorylation of both FAK and paxillin dose-dependently. 体内実験
BPC 157 (acetate) (10 ng/kg-10 μg/g, i.p.; 5 ng/g-50 μg/g, topical application as cream) promotes burn wound healing and alleviates burn-induced gastric injury in mice[2]. BPC 157 (acetate) (100 pg-10 μg/kg; i.p.; single dose) significantly alleviates haloperidol (HY-14538)-induced catalepsy in rats and inhibits gastric ulcers[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model: NMRI-Hannover (male, 30 g, deep partial skin thickness burns induced by 5 s direct flame exposure covering 20% total body area)[2] Dosage: i.p.: 10 ng/kg, 10 μg/kg; Topical: 5 ng/g, 50 ng/g, 500 ng/g, 5 μg/g, 50 μg/g Administration: topical (burn site, once daily); i.p. (once daily); starting immediately after burn and continuing until 24 hours before sacrifice Result: Improved all parameters related to burn wound healing (including reducing edema, inflammatory cell infiltration and necrosis, increasing the number of capillaries, reticulin and collagen fiber formation, preserving hair follicle count, enhancing wound re-epithelization rate, skin breaking strength and relative elongation, and decreasing water content in burned skin). Consistently attenuates burn-induced gastric mucosal lesions in the deep partial-thickness burn model of male NMRI-Hannover mice.
Animal Model: Wistar Albino (male, 200-220 g body weight)[3] Dosage: 10 μg/kg, 10 ng/kg (catalepsy and gastric ulcers); 1.0 ng/kg, 100 pg/kg (gastric ulcers only) Administration: i.p.; single dose Result: Reduced catalepsy duration on both horizontal bar and inclined wiremesh screen tests at all assessed time points. Inhibited gastric lesion development for all doses, with near-zero mean sum of lesion diameters and drastically reduced lesion incidence compared to controls. 分子量
1419.54 (free acid) 分子式
C62H98N16O22.xC2H4O2 CAS 番号
1628202-19-6 Appearance
Solid Color
White to off-white Sequence
Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val Sequence Shortening
GEPPPGKPADDAGLV 輸送条件
Room temperature in continental US; may vary elsewhere. 保管条件
Sealed storage, away from moisture Powder -80°C 2 years -20°C 1 year In solvent -80°C 6 months -20°C 1 month 溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
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純度: 99.78%
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取扱説明書 (2659 KB) 参考文献
[1]. Chang CH, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985). 2011;110(3):774-780. [Content Brief]
[2]. Mikus D, et al. Pentadecapeptide BPC 157 cream improves burn-wound healing and attenuates burn-gastric lesions in mice. Burns. 2001;27(8):817-827. [Content Brief]
[3]. Jelovac N, et al. Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats. Eur J Pharmacol. 1999;379(1):19-31. [Content Brief]
[1]. Chang CH, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985). 2011;110(3):774-780.
[2]. Mikus D, et al. Pentadecapeptide BPC 157 cream improves burn-wound healing and attenuates burn-gastric lesions in mice. Burns. 2001;27(8):817-827.
[3]. Jelovac N, et al. Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats. Eur J Pharmacol. 1999;379(1):19-31.
ペプチド Peptide and Derivatives Therapeutic Peptides
疾患領域 Neurological, Eye or Ear Disease Metabolic or Endocrine Disease
Neurological Disease Metabolic Disease
Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling JAK FAK
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一般には略語で表示されます:C1V1 = C2V2
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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
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